Witnesses reported seeing the plane crash while descending to Tribhuvan International Airport in Kathmandu, Nepal before crashing at a nearby football ground.
Officials have not confirmed the status of passengers but fatalities are expected after the plane erupted into flames after crashing.
Airport officials said 67 people were on board the plane when it crash-landed at the airport, skid off the runway and burst into flames.
Tourism Ministry Joint Secretary Suresh Acharya said 17 injured passengers were rushed to hospital. He did not confirm the status of the other passengers.
The plane is believed to have been travelling from Dhaka, the capital of Bangladesh, when it crashed in Kathmandu.
An aviation official said the plane lost control as it attempted to land.
Sanjiv Gautam said: “The aircraft was permitted to land from the Southern side of the runway flying over Koteshwor but it landed from the Northern side.
“We are yet to ascertain the reason behind the unusual landing.”
Nepal Plane Crash
Flight trackers Air Live said: “A Bangladesh passenger aircraft ‘became unstable’ while descending, crashes at Nepal’s Kathmandu airport – airport official.
“Casualties are feared after a plane crashed at the airport in Kathmandu, Nepal, sending a huge cloud of smoke into the air, say eyewitnesses.”
FlightRadar24 said the aircraft involved is a “17-year-old Bombardier Dash 8 Q400”.
A spokesman for the airport said: “We are trying to bring the fire under control. Details are awaited.”
An Airplane just crashed at the Kathmandu International Airport. I saw it when it happened. OMG! 2:20 pm #Nepal
— FrugalTravelsNepal (@FrugalTravelsNe) March 12, 2018
Nepal has suffered a number of air disasters in recent years, dealing a blow to its tourist industry. Its poor air safety record has been blamed largely on inadequate maintenance, inexperienced pilots, and substandard management.
In early 2016, a Twin Otter turboprop aircraft slammed into a mountainside in Nepal killing all 23 people on board.
Plumes of black smoke were seen rising from the football pitch minutes after the plane crashed, to the east of the runway at Nepal`s only international airport, in the capital Kathmandu.
Firefighters were immediately rushed to the spot to extinguish the burning wreckage and rescue passengers.
”So far 20 people injured have been taken to the hospital. Police and Army are trying to cut apart the plane to rescue others,” he added.